Susan is a middling-height woman. She's got wavy, honey colored hair, and brown eyes. She has a fairly light complexion. She wears a lab coat, which must have been white at some point, long since stained by dust and blood, from the wasteland and various patients, respectively.
She's a rather kind individual, or as close to one as you're like to find in the Wasteland. She's almost always willing to help out, though some might notice a faint, underlying loathing when in the presence of Ghouls, or other such mutants.
Henderson was one of the founding members of Overpass, in 2273. Since then, she ran a clinic in town, until sometime in late 2277, when she packed up and left with little explanation. It is fairly common knowledge however, that she moved to Niagara.